Lab Manager / Research Assistant Position at the Trinity Centre for Biomedical Engineering

The primary purpose of this role is to provide technical and administrative support to Prof Daniel Kelly’s research group within the Trinity Centre for Biomedical Engineering TCBE), with an emphasis on Tissue Engineering and 3D Bioprinting. In particular, the successful candidate will support the implementation of a European Research Council (ERC) grant awarded to Prof Daniel Kelly. The successful candidate will join a team of postdoctoral researchers and postgraduate students based in the TCBE.

CDT-ACM PhD Studentships

EPSRC and SFI Centre for Doctoral Training in the Advanced Characterisation of Materials

(CDT-ACM) PhD Studentships

Imperial College London, University College London & Trinity College Dublin

This advert is for Trinity College Dublin only

Duration: 48 months (starting on 1st September 2022)

Imperial College London, University College London (UCL) and Trinity College Dublin jointly offer a number of four-year fully-funded PhD studentships as part of the CDT-ACM. Successful applicants will be registered at either Imperial College London, University College London or Trinity College Dublin. This advert is for Trinity College Dublin applicants only.

The Advanced Materials and BioEngineering Centre (AMBER) is inviting applications for 7 PhD studentships to commence 1st September 2022. The studentships are part of the joint Science Foundation Ireland (SFI)-EPSRC funded Centre for Doctoral Training in the Advanced Characterisation of Materials (CDT-ACM) programme. SFI funding covers the stipend and fees as well as a research budget. Applicants must have been resident in an EU member state for 3 out of the last 5 years to be eligible for funding through this programme.

The CDT-ACM programme trains new scientists to become experts in the application of advanced analytical techniques for materials development. It offers training in the application of state-of-the-art characterisation techniques for materials challenges in five thematic key areas of societal importance:

Energy Materials
Biomaterials and Regenerative Medicine
Engineering Materials
Electronic and Magnetic Materials
Instrumentation & Technique Development

Each research project will involve experts from at least two of the universities, and you will spend time at all sites during your research and training. You will also undertake a placement for at least one month at a leading international university, research institute or industrial partner. Specially designed training modules in characterisation will be interwoven with your PhD research project, and you will also receive professional development training. Students will take taught courses at the London universities during the first three months of their training and will spend two weeks in Dublin afterwards for further training at the Advanced Microscopy Laboratory (AML).

The world-leading research that you will be involved with will be closely linked with real-world applications, as the projects will be aligned with the priorities of our network of industrial partners. On graduation you will be ideally qualified to follow a career path either in academia or industry. Our training philosophy is that our graduates will provide the innovation and creativity required to lead the world in the development, characterisation and manufacture of new materials, making a significant contribution to the quality of life of future generations.

The CDT seeks candidates for September 2022 entry. You will hold, or be expected to achieve, a Master’s degree or a 4 year undergraduate degree at 2:1 level (or above) in a relevant subject, e.g. Material Sciences, Physics, Chemistry, Earth Sciences, Mechanical, Electrical or Chemical Engineering.

If you are interested in both locations you will need to send two separate applications.

Research projects on offer are diverse and successful applicants will choose a project following discussions with project supervisors. Projects on offer for the 2022 cohort are available on the CDT-ACM website.

To make informal enquiries please contact Sandra Ellis on cdtacm@tcd.ie. Information on how to apply can be found on the CDT-ACM website.

Applications will be handled in two stages:

Stage 1: Suitable applicants will be interviewed by staff members of the CDT-ACM.

Stage 2: Successful applicants will be invited to make a formal application at Trinity College Dublin.

FUNDING CRITERIA FOR TCD APPLICANTS:

For EU students SFI funding covers fees and a stipend of €18,500 per annum together with a research budget for travel and consumables. Applicants must have been resident in an EU member state for 3 out of the last 5 years to be eligible for funding through this programme. International students are welcome to apply, however they must cover the international fee difference and provide evidence of ability to cover these costs at the application stage. For more details on eligibility check here.

Closing date: Friday 17th December 2021

Interviews will take place in early February 2022

https://www.findaphd.com/phds/program/advanced-materials-and-bioengineering-research-centre-amber-fully-funded-phd-studentships-at-trinity-college-dublin/?p4369

PhD studentships in AMBER

AMBER is inviting applications for the following PhD studentships which are open for enrolment. The AMBER research centre, as a community of researchers, welcomes its responsibility to provide equal opportunities for all. We are actively seeking diversity in our research teams and particularly encourage applications from underrepresented groups. Applicants must have been resident in an EU member state for 3 out of the last 5 years to be eligible for funding through this programme.

To apply – please e-mail a CV with the names and addresses of three referees to the lead supervisor listed above, contact details can be found within project PDF.

Positions will remain opened until filled. Only short-listed applications will be acknowledged.

3D printing of fibrous electroconductive biomaterials with controlled architectures for peripheral n

3D printing of fibrous electroconductive biomaterials with controlled architectures for peripheral nerve repair

The position will be based with the Buckley Lab (www.buckleylab.eu) within the Advanced Materials and Bioengineering Research (AMBER) centre. Prof. Buckley leads a multidisciplinary research group in the Trinity Centre for Biomedical Engineering at Trinity College Dublin. The goal of the Buckley lab is to develop novel biomaterial and cell-based strategies to regenerate or repair damaged tissues to restore function using minimally invasive strategies (MIS).

Summary of project

Peripheral nerve injury remains a major clinical problem. Autografts are the current ‘gold standard’ but are hampered by limited availability of donor tissue with poor prognosis for functional recovery at both the donor and recipient sites. As a result, new approaches are currently being investigated to develop artificial nerve grafts which mimic the properties of autologous grafts. Additive manufacturing (AM) techniques such as 3D bioprinting (3DBP) offers exciting new opportunities and horizons to engineer nerve guidance conduits (NGCs) that more closely match the composition and structure of native nerve tissue. These approaches facilitate precise control over the external and internal microarchitecture geometry. In the context of developing engineered nerve tissue AM offers the added ability to incorporate drug delivery systems with tailorable spatial and temporal release profiles of individual drugs. Similarly, following peripheral nerve injury, the transfer of electrical signals across a damaged nerve is inhibited, resulting in degeneration of the distal nerve segment. Printing offers the potential to create specific geometries with defined micropatterns as well as incorporating electroconductive biomaterials to provide direct electrical activation to enhance tissue repair, enhance cell function and alignment. Applying electrical stimuli may enhance the regeneration as it is known that inhibition of electrical signalling can impede normal tissue function. Using bioinks derived from native nerve as a biomaterial platform developed in the Buckley lab for peripheral nerve tissue regeneration, this project proposes to enhance regenerative capacity of NGCs through the incorporation of electroconductive materials from partner labs in AMBER (e.g. graphene, silver nanowires, polypyrrole). Such a conductive biomaterial could thus provide direct electrical activation of isolated regions while also providing a scaffolding template to enhance the tissue repair process. Following optimisation of the fabrication/printing process, in vitro biocompatibility of the biofabricated NGCs and the response of cells to electrical stimuli will be assessed using in vitro methods prior to pre-clinical assessment. For more information please contact Prof. Conor Buckley conor.buckley@tcd.ie

Tissue-derived Bioinks for 3D Printing Applications- Material Characterisation, Biocompatibility and

Tissue-derived Bioinks for 3D Printing Applications- Material Characterisation, Biocompatibility and Immunomodulatory Behaviour

Project Description: This project is part of multidisciplinary team that is exploring the use of emerging 3D Printing and 3D Bioprinting strategies for Tissue Engineering and the development of next generation medical devices. The project is part of the AMBER centre (http://ambercentre.ie) and located primarily at dedicated bioprinting and additive manufacturing laboratories based in Trinity College Dublin. With the advent of 3D printing in tissue engineering, the advantages of precise deposition and highly defined geometric patterning 3D biomaterial structures that it offers, efforts have been made to combine the benefits of ECM hydrogels with this technology. However, many of the existing ECM bioinks lack the necessary physiologically relevant mechanical properties, e.g. compressive strength, especially for application to high load environments in musculoskeletal, or high wear environments such as the cardiovascular system. Other drawbacks include slow thermogelation times, hindering printing speeds, and rapid degradation times, limiting their potential active therapeutic window for in vivo applications. Further chemical functionalisation of the ECM through the incorporation of photoactive moieties to the collagen fibre backbone allows for light polymerised photogelation, increased polymer network crosslinking, and improved tuning of material properties. To this end, we are developing a range of photoactive ECM shear thinning hydrogels, which can be used as injectable therapeutics or as bioinks for 3D bioprinting applications. This approach aims to combine the intrinsic regenerative potential of ECM and engineering precision of 3D printing, with distinct improvements in material and mechanical properties. In addition, understanding how these bioinks influence macrophage phenotype is important for in vivo applications. Engineering an appropriate immune response is integral to successful tissue regeneration given its importance to clearing damaged cells and tissue, recruiting host stem cells and inducing vascularization. For more information please contact Prof. Conor Buckley conor.buckley@tcd.ie

Applicant criteria: The ideal applicant will have a PhD in biomedical engineering, biomaterials, tissue engineering, biochemistry and immunology or a related discipline. Previous experience in 3D printing, hydrogels, tissue engineering, cell culture, gene expression, biochemical analysis, mechanical testing, histology techniques, immunomodulatory behaviour would be highly advantageous. Excellent written and oral communication skills are essential. An excellent publication record and/or development of intellectual property would be advantageous.
How to apply: CVs with the names and addresses of three referees should be submitted via email to Prof. Conor Buckley conor.buckley@tcd.ie with the subject heading “AMBER-Bioink Postdoc”. Positions will remain opened until filled but preferred start date is January 2021. Only short-listed applications will be acknowledged.

Postdoctoral Researcher in 3D Bioprinting and Tissue Engineering

The development of novel additive biomanufacturing strategies to tissue engineer hybrid implants for synovial joint regeneration

Project Description: The successful applicant will join a multidisciplinary team that is exploring the use of emerging 3D bioprinting strategies for Tissue Engineering and the development of next generation medical devices. The overall goal of the project is to develop a new class of 3D bioprinted biological implant that will regenerate, rather than replace, diseased joints. This will be realised by integrating developments in the 3D printing of metals, biodegradable polymers and cell-laden bioinks to develop hybrid biological devices, using dedicated bioprinting and additive manufacturing laboratories based in Trinity College Dublin. The successful applicant will specifically focus on integrating 3D printed metal implants with tissue engineered articular cartilage to develop hybrid implants for resurfacing the hip joint. The overall project is a collaboration between the Advanced Materials and Bioengineering Research (AMBER) centre, DePuy Ireland Unlimited Company and Johnson & Johnson Services, Inc.

For more information please contact Prof. Daniel Kelly (kellyd9@tcd.ie).

Applicant criteria: The ideal applicant will have a PhD in biomaterials, tissue engineering, 3D printing or a related subject. Previous experience in 3D (bio)printing, hydrogels, tissue engineering, cell culture, biochemical analysis, mechanical testing, histology techniques would be highly advantageous. Excellent written and oral communication skills are essential.

Start Date: From January 2021 onwards; position will remain open until it is filled.

How to apply: CVs with the names and contact details of three referees should be submitted via email to Prof. Daniel Kelly (kellyd9@tcd.ie).